Demonstration of T-Cell Monotypia Using Anti-TCRbeta1/2 (TRBC1/2) Immunostaining as a Rapid and Cost-Effective Alternative to PCR-Based Clonality Studies for the Diagnosis of T-Cell Lymphoma.
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Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency.
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Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs.
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Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury.
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FILAGGRIN INSUFFICIENCY AFFECTS LONG-DISTANT COMMUNICATION MEDIATED BY KERATINOCYTE-DERIVED SMALL EXTRACELLULAR VESICLES AND PROMOTES ALLERGIC INFLAMMATION
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Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of affecting CD1a-mediated T-cell responses and promoting allergic inflammation
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Phospholipase activity of acyloxyacyl hydrolase induces IL-22-producing CD1a-autoreactive T cells in individuals with psoriasis.
Singh R. et al, (2022), Eur J Immunol, 52, 511 - 524
Filaggrin segregates into keratinocyte-derived exosomes which can be found in the blood: more than skin deep?
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Unbiased single cell spatial analysis localises inflammatory clusters of immature neutrophils-CD8 T cells to alveolar progenitor cells in fatal COVID-19 lungs
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A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium None. et al, (2021)
Use of T Cell-Specific RNA In Situ Hybridisation as a Novel Test to Distinguish Malignant (Lymphomatous) and Benign (Inflammatory) T Cell Infiltrates
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