Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

Websites

Alastair Smith

Postdoctoral Researcher

Brief biography and current research interests

I joined the Milne Lab in 2018 after completing my PhD, where I investigated the temporal regulation of transcription in V(D)J recombination. My current research focuses on the emergence and function of novel enhancers in leukaemia, with a particular emphasis on MLL-AF4 Acute Lymphoblastic Leukaemia (ALL).

To investigate chromatin regulation and gene expression, I apply a broad suite of high-throughput and integrative approaches. These include ChIP-seq, low-input ChIPmentation, ATAC-seq, RNA-seq, Capture-C, CUT&Tag, single-cell multiomics, and DNA methylation profiling. I combine these data with machine learning and advanced bioinformatic methods to uncover mechanisms of transcriptional dysregulation in leukaemia.